Biospecimens are usually kept in storage for the majority of their “lifetimes,” but the brief moments when they are being transferred are the moments they are most at risk. Regardless of whether the purpose for transfer is consolidation, storage reorganization or replacing damaged containers, maintaining the appropriate temperature for the type of samples and their… Read article →
Formalin fixation and paraffin embedding (FFPE) can impair the quality of nucleic acids obtained from tissue samples. The molecular analysis of FFPE samples is negatively affected by the low quality of analytes from FFPE samples. Taking this into consideration is important when performing successful molecular analyses. In this post, we’ll discuss how FFPE affects RNA… Read article →
Formalin-fixed, paraffin-embedded (FFPE) tissue is the most common specimen available for molecular assays on tissue after diagnostic histopathological examination (1). These tissue samples can also provide valuable sources of stable nucleic acids for research as part of biobanks, but poor recovery and quality of nucleic acids from FFPE tissue specimens often affects the accuracy and… Read article →
The process of retrieving analytes from formalin-fixed paraffin-embedded (FFPE) tissue samples is an incredibly complicated endeavor. There are several major challenges when purifying DNA, RNA and protein from FFPE samples. First, these biomolecules are crosslinked to each other. Second, nucleic acids are often fragmented depending how the FFPE samples are prepared, and third, there is… Read article →
The archives of formalin-fixed paraffin-embedded (FFPE) tissue sections stored around the world represent a valuable and extensive source of material for biomedical research. With more researchers turning towards molecular analysis of FFPE samples, it is becoming increasingly important to develop specific protocols that take into consideration the unique nature of these samples. The complete FFPE… Read article →
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