General

miRNA_RISC_Ribosomes_700x233

Emerging roles of competing endogenous RNA (ceRNA)

If you have been following our blog posts about microRNA (miRNA) – or if you have been studying the microRNA world – you are likely familiar with the small 22-nucleotide RNAs that target messenger RNAs (mRNAs) to repress their translation into protein. The ceRNA hypothesis In 2011, Pier Paolo Pandolfi research lab proposed the hypothesis… Read article →


TerminalDifferentiationMarkers_700x233

Cannabis epigenetic control of skin differentiation genes

Did you know that there is a “Hash, Marihuana & Hemp Museum” located in Amsterdam, Netherlands? Dedicated to education and scientific studies, this world-famous museum has received more than 2 million visitors since 1985. Despite its controversial uses and long banning histories, cannabis (commonly referred to as marijuana) and its chemical derivatives have been found… Read article →


cfDNA_Discoveries_700x233

How to optimize the preanalytical portion of your circulating cell-free DNA (cfDNA) studies

Advances in liquid biopsy are allowing new strides in studies involving circulating cell-free DNA (cfDNA). With initial use in the prenatal testing field, cfDNA began to tell its story in fetal DNA genetic testing and has offered an alternative to the invasive and risk-prone amniocentesis. Now, it is breaking barriers in the field of cancer… Read article →



CirculatingTumorCells_700x233

HER2-positive circulating tumor cells in primary breast cancer patients with HER2-negative tumors

In metastatic breast cancer patients, the presence of circulating tumor cells (CTCs) in the blood predicts shorter progression-free survival and lower overall survival (1). Persistent CTCs after treatment also predict a lack of therapeutic response (2). Although the prognostic significance of CTCs in metastatic patients is well established, fewer studies have examined CTCs in primary… Read article →