Circulating Nucleic Acids

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Peer into your child’s future – medically, not astrologically!

I’ve been following noninvasive prenatal testing (NIPT) technology very closely, as QIAGEN is becoming a pioneer in providing solutions for liquid biopsy-based research. Liquid biopsy is considered by many to have great potential in the future for predictive diagnostics. Recently, I came across an interesting news article on CNN Frontiers, focusing on the scientist who first discovered… Read article →


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Analyzing fragmentation footprints in cell-free DNA

In the field of liquid biopsy, one of the challenges is identifying the cellular source of biological material. For example, current methods for analyzing circulating tumor DNA (ctDNA) rely upon genetic differences to distinguish ctDNA from cell-free DNA (cfDNA) released by normal cells. Because ctDNA represents only a small fraction of total circulating DNA, tumor-specific… Read article →


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Tackle the challenges of circulating tumor DNA (ctDNA) research and non-invasive prenatal testing (NIPT)

At the frontier of liquid biopsy, NIPT (noninvasive prenatal testing) is increasingly being used to screen and test chromosomal abnormalities by analyzing cell-free fetal DNA circulating in maternal blood. Similarly, since disease-specific mutations or alterations of the circulating cell-free DNA (cfDNA) are frequently found in serum samples of cancer patients, research into cctDNA testing as… Read article →


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Now trending: the use of liquid biopsy to monitor tumor dynamics

Trends on social media and internet search engines can be used as tools to provide up-to-the-minute public opinion on just about any topic, from movies to presidential candidates. Liquid biopsy may be able to provide the same type of real-time (although not instantaneous) information about therapeutic efficacy as well as emerging drug resistance. Solid tumor… Read article →


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Webinar download: Automate and standardize processes for cell-free DNA in liquid biopsy

Circulating, cell-free DNA (cfDNA), which can originate from malignant tumors, the developing fetus or inflammatory tissues, is present among the cell-free nucleic acids in plasma, serum and other body fluids. Recently, cfDNA has become a powerful tool in non-invasive prenatal testing (NIPT), as well as in liquid biopsy for cancer. Analysis of cfDNA allows for… Read article →