Circulating Tumor Cells

EMT

New ideas abound at ACTC 2017: Mitochondria and metastasis, new prostate cancer CTC tools and more!

The 3rd ACTC Advances in Circulating Tumor Cells Conference was held in Rhodes, Greece October 4-7, 2017. This idyllic island setting off the coast of Turkey provided a relaxed and welcoming atmosphere for discussing the latest advances in cancer and circulating tumor cell research. Talks were divided into 6 plenary lecture sessions consisting of: (1)… Read article →



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Breaking the metastasis cycle: Is ROS-activated β-globin expression required for CTC survival?

Reactive oxygen species (ROS) are chemical molecules containing a highly reactive oxygen molecule. These molecules are formed as by-products of cellular metabolism, but also serve intracellularly as signaling molecules. ROS examples include peroxides, superoxide, hydroxyl radical and singlet oxygen. When present within cells in significant amounts, ROS can be indicators of oxidative cellular stress, and… Read article →



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New webinar: HER2, CTCs and tumor stemness

About 20–30% of breast cancer tumors overexpress the oncogene human epidermal growth factor receptor 2 (HER2), which – if not treated with a targeted anti-HER2 regimen – leads to higher aggressiveness and mortality. Recently, a number of studies have shown that expression of HER2 in circulating tumor cells (CTCs) varies compared to expression in primary tumors…. Read article →