Circulating Tumor Cells

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Breaking the metastasis cycle: Is ROS-activated β-globin expression required for CTC survival?

Reactive oxygen species (ROS) are chemical molecules containing a highly reactive oxygen molecule. These molecules are formed as by-products of cellular metabolism, but also serve intracellularly as signaling molecules. ROS examples include peroxides, superoxide, hydroxyl radical and singlet oxygen. When present within cells in significant amounts, ROS can be indicators of oxidative cellular stress, and… Read article →



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New webinar: HER2, CTCs and tumor stemness

About 20–30% of breast cancer tumors overexpress the oncogene human epidermal growth factor receptor 2 (HER2), which – if not treated with a targeted anti-HER2 regimen – leads to higher aggressiveness and mortality. Recently, a number of studies have shown that expression of HER2 in circulating tumor cells (CTCs) varies compared to expression in primary tumors…. Read article →


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Top 10 FAQs on circulating tumor cells

During the past 20 years, the interest in circulating tumor cells (CTCs) has increased dramatically due to their potential as circulating biomarkers in monitoring cancer progression and treatment. However, selecting and detecting CTCs from whole blood of cancer patients in the background of normal cells is very challenging. Since last summer, Dr. Siegfried Hauch, Director… Read article →


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Towards personalized cancer care: liquid biopsy for monitoring primary breast cancer

Breast cancer is the most common cancer in women, accounting for 23% of all cancer diagnoses (1). At the time of diagnosis, a majority of patients (>90%) will have localized disease, which is typically treated with surgery, radiation and therapeutic agents. Localized disease is associated with improved five-year survival rates, relative to more advanced cancers… Read article →