Circulating Tumor Cells


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CTCs as prognostic markers for metastatic breast cancer

Circulating tumor cells (CTCs) are tumor cells circulating freely in the peripheral blood of patients. The characterization of CTCs is considered as a real-time “liquid biopsy” that provides an ongoing picture of a patient’s cancer status, offering valuable insight into personalized anticancer therapy. CTCs are very rare and highly heterogeneous, possessing tumor-specific antigenic and genetic characteristics. One… Read article →


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Tracking cancer with liquid biopsy

The advent of personalized medicine has created the need for simple, accurate and minimally invasive methods to repeatedly assess the genotype of patients’ tumors. Liquid biopsy, the use of body fluids as an alternative to tissue biopsy, has emerged as the next technological advance in cancer diagnosis and treatment. Three approaches to liquid biopsy have… Read article →


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CTC enrichment: methods and critical steps

Circulating tumor cells (CTCs), cells that have detached from the primary tumor and entered the peripheral blood, are emerging as a significant source of genetic material for clinical guidance. However, the relative rarity of these cells, between 1–10 cells per 10 ml in most patients (1), makes it challenging to unlock their potential. Separating CTCs… Read article →


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Molecular characterization of circulating tumor cells

Although circulating tumor cells (CTCs) hold a wealth of information, the only clinically approved use of CTCs is enumeration for the prediction of progression-free survival and overall survival. The use of CTCs for prognosis is groundbreaking, but specifically enriching and counting tumor cells does not fully exploit the information available in CTCs. A real‑world analogy… Read article →