Non-coding RNA

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Biofluid microRNA profiling

The development of biomarkers will be essential for the future of diagnostic, prognostic and predictive medicine. Diagnostic biomarkers may be used to detect cancer, heart failure, stroke or a number of other diseases. Prognostic biomarkers predict patient outcome, while predictive biomarkers are essential for determining whether a cancer patient will respond to targeted therapy. Unfortunately, the translation… Read article →


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Multiple sclerosis: hunting for new RNA markers in blood

Multiple sclerosis (MS), a rare and chronic central nervous system disorder resulting from autoimmunity, occasionally steps into the public eye when it strikes a well-known person (such as in 1999, when talk show host Montel Williams revealed his diagnosis). In neuroscience and immunology laboratories, however, the disease is always a major topic of investigation. Researchers… Read article →


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Neurodegeneration: role of noncoding RNA in molecular mechanisms

Neurodegeneration is characterized by cumulative dysfunction and death of cells in selected areas of the nervous system. Neurodegenerative disorders typically present in old age with symptoms related to movement and cognition. The greatest burden of disease in the US, by number of individuals affected, is caused by Alzheimer’s disease (AD) (1). Characteristics of AD include… Read article →


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Join us to learn how lncRNA impacts cancer and microRNA regulation!

Long noncoding RNA are a non-protein-coding RNA species >200 nt in length that have been the subject of intense scrutiny recently. Research in the last several years has revealed roles for lncRNA in gene regulation at many levels – transcription, post-transcription, and in epigenetic modification. Many lncRNAs are dysregulated in various cancer types and are… Read article →


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Micropeptides: a twist in the lncRNA story

Long noncoding RNA (lncRNA) research has exploded in recent years, indicating potential roles for these molecules in regulation of gene expression at the transcriptional, post-transcriptional and epigenetic levels. Recently, an even greater level of complexity was introduced with the realization that some RNAs currently classified as lncRNAs are apparently not noncoding after all. While they’re… Read article →