Non-coding RNA


Micropeptides: a twist in the lncRNA story

Long noncoding RNA (lncRNA) research has exploded in recent years, indicating potential roles for these molecules in regulation of gene expression at the transcriptional, post-transcriptional and epigenetic levels. Recently, an even greater level of complexity was introduced with the realization that some RNAs currently classified as lncRNAs are apparently not noncoding after all. While they’re… Read article →


microRNAs in cancer metastasis: potential for therapy and liquid biopsy

For patients with solid tumors, metastatic disease often represents a turning point in their journey. It remains the most significant hurdle in cancer treatment, accounting for 90% of all deaths resulting from solid tumors (1). Research during the past 20 years has begun to elucidate multiple events that take place during metastatic progression. In the… Read article →


Cancer in the lungs? The blood will tell – miRNA in non-small cell lung cancer

In a previous post, we discussed how small non-coding RNAs could be identified to serve as circulating biomarkers in lung cancer. Now, a new study from Ma et al. defines a promising microRNA signature in peripheral blood mononuclear cells. The signature can distinguish non-small cell lung carcinoma (NSCLC) with 72.62% sensitivity and 82.61% specificity, and squamous… Read article →