Liquid Biopsy


Maximizing quantity and purity of exosomal RNA for liquid biopsy

Exosomes are small membrane-bound vesicles ranging in size from 30 to 100 nm. They have been successfully isolated from multiple biofluids, including blood, plasma, urine and cerebrospinal fluid, and are being increasingly investigated for use in liquid biopsy. Although their primary function was once thought to be waste removal, further study has determined that exosomes… Read article →


Big things in small packages for liquid biopsy: extracellular communication via exosomes

Cells utilize multiple mechanisms to send messages. Long-range signaling, the production of molecules from a single organ which then travel through the bloodstream to the rest of the body, is regulated by the endocrine system. Signaling molecules secreted by the endocrine system include steroid hormones, growth factors, glycoproteins and catecholamines. The list of endocrine organs… Read article →

ILLU_0198_GG_Alzheimers_Disease (1)

Brainy exosomes: a novel pool for biomarker discovery in human CSF

Exosomes, endocytic vesicles ranging in size from 40–100nm, have revolutionized the field of cell–cell communication. Although they were first described in the 1980s, detailed analysis of exosome biogenesis, composition and function has occurred primarily within the past decade. The significance of exosomes is enhanced by the fact that exosomes transport packets of cellular information rather… Read article →


microRNAs in cancer metastasis: potential for therapy and liquid biopsy

For patients with solid tumors, metastatic disease often represents a turning point in their journey. It remains the most significant hurdle in cancer treatment, accounting for 90% of all deaths resulting from solid tumors (1). Research during the past 20 years has begun to elucidate multiple events that take place during metastatic progression. In the… Read article →


Cancer in the lungs? The blood will tell – miRNA in non-small cell lung cancer

In a previous post, we discussed how small non-coding RNAs could be identified to serve as circulating biomarkers in lung cancer. Now, a new study from Ma et al. defines a promising microRNA signature in peripheral blood mononuclear cells. The signature can distinguish non-small cell lung carcinoma (NSCLC) with 72.62% sensitivity and 82.61% specificity, and squamous… Read article →