Liquid Biopsy

ILLU_0198_GG_Alzheimers_Disease (1)

Brainy exosomes: a novel pool for biomarker discovery in human CSF

Exosomes, endocytic vesicles ranging in size from 40–100nm, have revolutionized the field of cell–cell communication. Although they were first described in the 1980s, detailed analysis of exosome biogenesis, composition and function has occurred primarily within the past decade. The significance of exosomes is enhanced by the fact that exosomes transport packets of cellular information rather… Read article →


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microRNAs in cancer metastasis: potential for therapy and liquid biopsy

For patients with solid tumors, metastatic disease often represents a turning point in their journey. It remains the most significant hurdle in cancer treatment, accounting for 90% of all deaths resulting from solid tumors (1). Research during the past 20 years has begun to elucidate multiple events that take place during metastatic progression. In the… Read article →


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Cancer in the lungs? The blood will tell – miRNA in non-small cell lung cancer

In a previous post, we discussed how small non-coding RNAs could be identified to serve as circulating biomarkers in lung cancer. Now, a new study from Ma et al. defines a promising microRNA signature in peripheral blood mononuclear cells. The signature can distinguish non-small cell lung carcinoma (NSCLC) with 72.62% sensitivity and 82.61% specificity, and squamous… Read article →


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Tumor-derived exosomes

Tumor cells utilize multiple signaling mechanisms to modify surrounding tissue and create a favorable environment for growth and metastasis. Direct cell–cell communication is mediated by gap junctions, which are specialized channels that allow the transfer of ions and small molecules between adjacent cells. Paracrine signaling molecules, such as TGF-beta and fibroblast growth factor, act over a… Read article →