Liquid Biopsy

microRNA and lncRNA in lung cancer

miRNA and lncRNA – serum biomarkers for lung cancer

One of the most exciting potential applications of circulating non-coding RNAs like microRNA (miRNA) and long non-coding RNA (lncRNA) is as biomarkers for early detection of cancer. Cancer treatment, like treatment of many other diseases, can be far more effective when started early. Easily accessible markers like RNAs in the blood are an attractive possibility for finding… Read article →


next-generation sequencing

From sample to insight: NGS for liquid biopsy and beyond

The use of high-throughput next-generation sequencing (NGS) technologies continues to provide a wealth of sequence data, resulting in significant advances in a wide range of research areas and applications. Key among these is liquid biopsy – the ability to sequence nucleic acids found in circulation will enable scientists to identify key mutations and more specifically distinguish… Read article →


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Circulating Biomarkers World Congress 2015

In March, the second annual SELECTBIO Circulating Biomarkers World Congress 2015 brought together academic researchers and industry participants to present research, industry and commercial activities in the translation of circulating biomarkers. Speakers presented unpublished data on extracellular vesicles and extracellular nucleic acids as circulating biomarkers, fitting into three overarching themes: • Circulating DNA, RNA and… Read article →


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Profiling microRNA from exosomes and blood

Exosomes are nano-sized vesicles, secreted by all types of cells and found abundantly in biofluids like blood, saliva and urine. These extracellular vesicles carry multiple functional passengers including DNA, miRNA, non-coding RNA and proteins, and function as intercellular communication vehicles by transporting molecules between specific cells. microRNAs are small non-coding RNAs that play an intricate… Read article →


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Getting insight into the body: it’s all about the blood

Blood tells us lots of things. From cardiovascular health to cholesterol to inflammation to vitamin D levels – there is no shortage of information. Historically, blood was used to determine physiological and biochemical states, such as disease and organ function – but now, there are new technologies being developed to run the next generation of… Read article →