microRNA Biomarkers

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Extending miRQC – delving deeper into miRNA platform performance

Recently, QIAGEN set out to investigate the performance of its market-leading miRNA testing platform. A key study released in 2014, the microRNA Quality Control Assessment (miRQC), examined the performance of a number of miRNA quantification systems, including the QIAGEN miScript System. In that study, QIAGEN performed quite well, showing high levels of reproducibility, accuracy and… Read article →


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A webinar with Dr. Jo Vandesompele – Expanding the dynamic range of microRNA expression

In 2014, an ambitious microRNA technology study was published in Nature Methods. This study evaluated the existing microRNA platforms on the market for their technical performance. The authors, including first author Pieter Mestdagh and corresponding author Jo Vandesompele of Ghent University and Biogazelle, found small differences between the qPCR technologies, but concluded that from this purely technical perspective, there was no… Read article →


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Why preamplify in miRNA research? Download the white paper

It’s hard to overstate the importance of amplification technology in molecular biology. Reverse transcription-polymerase chain reaction (RT-PCR) amplifies sections of messenger RNA so they can be quantified – we’d have a much dimmer view of the transcriptome without it. Whole-genome amplification helps us analyze genes in single or limited cells, opening up a whole new… Read article →


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Signs of an overdose – microRNAs identify drug toxicity

When we think of drug overdoses, we typically think of controlled substances – e.g., illegal drugs or prescription drug abuse. It might come as a surprise, then, to hear that overdose of acetaminophen (APAP), the common over-the-counter analgesic used for headaches, fevers, and other minor ailments, is also a serious public health concern. Data from… Read article →


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From the archives: microRNA and the ECM in metastasis, a minireview

These days, everyone’s excited about the potential of circulating microRNAs to be biomarkers for disease, and justifiably so. They’re stable, they’re measurable, and they’re showing a lot of promise for a wide range of diseases. Beyond their potential as biomarkers, they’re also powerful regulators of normal and disease processes via gene regulation, and therefore a hot… Read article →