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microRNA Biomarkers

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Signs of an overdose – microRNAs identify drug toxicity

When we think of drug overdoses, we typically think of controlled substances – e.g., illegal drugs or prescription drug abuse. It might come as a surprise, then, to hear that overdose of acetaminophen (APAP), the common over-the-counter analgesic used for headaches, fevers, and other minor ailments, is also a serious public health concern. Data from… Read article →

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From the archives: microRNA and the ECM in metastasis, a minireview

These days, everyone’s excited about the potential of circulating microRNAs to be biomarkers for disease, and justifiably so. They’re stable, they’re measurable, and they’re showing a lot of promise for a wide range of diseases. Beyond their potential as biomarkers, they’re also powerful regulators of normal and disease processes via gene regulation, and therefore a hot… Read article →

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Putting the reins on immunity – using microRNAs to monitor autoimmune therapy

The mammalian immune system is a complex, lethal collection of cells and molecules that controls and eliminates threats to the body. The innate branch launches a quick response from phagocytes and natural killer cells, while the adaptive branch generates memory cells to create long-lasting defense against a second exposure. However, the immune system isn’t foolproof…. Read article →

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Where to tread carefully – how to ensure reliability in microRNA biomarker studies

Accuracy, reliable controls and reproducibility. These are the foundations on which a healthy scientific literature is based. When we read papers, we check the methods section to see how the authors controlled for certain variables, whether the technologies used were appropriate for the question, and how many times the experiments were replicated. Everyone wants to find the… Read article →

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