Cancer biomarkers are critical at multiple points during the disease process. Novel biomarkers for cancer screening, obtained via liquid biopsies, would be of particular clinical value given the difficulty of early detection for lethal malignancies such as ovarian and pancreatic cancer. Even cancers that are easily detected could benefit from improved screening and staging methods…. Read article →
One of the most exciting potential applications of circulating non-coding RNAs like microRNA (miRNA) and long non-coding RNA (lncRNA) is as biomarkers for early detection of cancer. Cancer treatment, like treatment of many other diseases, can be far more effective when started early. Easily accessible markers like RNAs in the blood are an attractive possibility for finding… Read article →
Improving tissue regeneration after myocardial infarction is an important goal in cardiovascular research, to reduce the risk of recurring infarction and heart failure. Cell replacement therapy using stem cells has long been thought to be a key for repairing the heart after injury, but many roadblocks stand in the way of turning this hope into… Read article →
Exosomes are nano-sized vesicles, secreted by all types of cells and found abundantly in biofluids like blood, saliva and urine. These extracellular vesicles carry multiple functional passengers including DNA, miRNA, non-coding RNA and proteins, and function as intercellular communication vehicles by transporting molecules between specific cells. microRNAs are small non-coding RNAs that play an intricate… Read article →
Mature microRNAs are the master regulators of gene expression and exhibit prominent roles in both normal and disease biologic processes. Since Victor Ambros and colleagues discovered the first miRNA in 1993, the microRNA universe has rapidly expanded. As of miRBase (miRBase.org) V21, there are 35,828 microRNAs across 223 species! For human alone, there are an… Read article →
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