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Precision medicine offers to transform patient care by targeting treatment to those with the most to gain. To date, the most significant advances have been at the DNA level. Development of RNA expression signatures as biomarkers has been more problematic. While RNA expression analysis has yielded valuable insights into the biological mechanisms of disease, RNA… Read article →
DNA purification is a critical step for obtaining accurate NGS data, because the quality of your starting material determines the reliability of next-generation sequencing results and data analysis. Even the best and most robust NGS technologies can only provide reliable results if the template nucleic acid is of adequate quality and purity. DNA purity is especially important at target… Read article →
In vivo studies and in vitro apoptosis assays show that cells do not die at the same time or at the same dose of a pharmacologic agent. This cell-to-cell variability is the net result of both genetic and non-genetic events. Understanding the determinants of the variability will help us develop multi-target treatment strategies that will… Read article →
DNA sequence information is important for virtually all branches of biomedical research. Given the genetic aspect of the disease, cancer research is at the forefront of DNA sequencing efforts. Next-generation sequencing (NGS) has been adopted as a technology of choice for cataloging mutations that can be translated into new diagnostic, prognostic and therapeutic targets. In… Read article →