NGS Pre-Analytics

Biogenesis

miRNA-seq – when should you use it, and what are the challenges?

Exploring microRNA expression and function has led to some important discoveries about the regulation of gene expression in normal biological processes and disease states, and has even recently given rise to unique circulating biomarker signatures. qPCR and microarrays are the traditional techniques used to assess microRNA expression, and they have their strong points – qPCR… Read article →


ILLU_0302_GG_Heat_Shock_Proteins

Keep calm, the chaperones are on!

The original nano-machines I was quite excited to hear the announcement that the 2016 Nobel Prize in Chemistry was awarded to a group of 3 European scientists for developing “nano-machines,” a technological breakthrough which crafted the path for the world’s first smart materials. Sir Fraser Stoddart, Bernard Feringa and Jean-Pierre Sauvage developed the world´s smallest… Read article →


QIAseq_ProductFamily_700x233

Novel digital sequencing technology promises to advance oncology research

As research uncovers the underlying mutations and mechanisms that drive oncogenesis and cancer progression, it’s becoming clearer that cures are likely to come not from a single silver bullet, but from identifying each individual’s personal cancer drivers. Next-generation sequencing (NGS) is the leading strategy for finding sequence variants and fusion genes responsible for cancer, and targeted… Read article →


QIAseq_miRNA_MCF_1000

Missing half your microRNA sequencing data? This is how you get it back.

Want to discover a new circulating miRNA biomarker, or characterize the miRNome of a new species? microRNA sequencing is the future of gene regulation analysis, providing unmatched specificity for closely related microRNAs as well as the ability to detect novel noncoding transcripts. But challenges in the current workflow can cause up to half of microRNA… Read article →


ILLU_1039_single_cell_genomics

All you need is ONE – focusing on the unmet needs of single cell research

Browse through PubMed and perform a search with keywords like transcriptomics, proteomics, genomics, sequencing or amplification. Pick any paper answering questions in cancer research, neurobiology, stem cell biology, immunology or developmental biology. Are you amazed by how often you come across the term “single-cell”? Don’t be! The field of single-cell analysis has grown enormously in the recent years. Nature… Read article →