Single Cell Analysis

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Detection of chromosomal rearrangements

Recently in Nature, Cheng-Zhong Zhang and colleagues published a very interesting approach that provides the first direct experimental evidence for a mechanism leading to chromothripsis (1). What exactly is chromothripsis? Zhang’s publication piqued my interest to dig a bit deeper into this phenomenon. Chromothripsis is a kind of catastrophic mutational event that results in massive rearrangements… Read article →



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Meet the challenges of single cell analysis

Single cell analysis is crucial for studying cellular diversity and heterogeneity in a complex mixture of materials. Whether you’re studying single cell genomics, circulating tumor cells or the microbiome, analyzing single cells creates the potential for deep understanding of cell heterogeneity. But several challenges stand in the way of this goal, such as allelic drop-out,… Read article →


Sequencing_Bacteria_700x233

If you can’t grow it, you can’t study it. How can we sequence unculturable bacteria?

Sequencing bacteria helps us detect mutations that might be important for antibiotic resistance, virulence changes and other variations within a species. A major complication, though, is the fact that not every bacterium can be successfully grown in culture. So how can you sequence something when you can’t culture it? A recent study points to the… Read article →