Exosomes

Is ultracentrifugation still the gold standard for exosome isolation?

There’s a new, proven method that may be knocking ultracentrifugation from its perch. Liquid biopsies and biomarker research depend on reliable access to exosomes and other extracellular vesicles (EVs), but standard ultracentrifugation-based protocols are laborious and don’t yield standardized results. Traditional ultracentrifugation-based protocols to isolate EVs are labor-intensive and subject to significant variability. Various attempts to… Read article →


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Small RNAs in small samples – what’s the value in single-cell microRNA analysis?

microRNA profiling has revolutionized our understanding of gene regulation. Technological advances are now enabling us to drill down further to the fine details – small RNA sequencing to identify undiscovered microRNAs, for example, preamplification to improve qPCR results from small samples and kits to reveal the small RNA contents of exosomes. Single-cell analysis is an… Read article →



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Could microRNAs be potential biomarkers for autism?

The attention in recent years surrounding the falsified Andrew Wakefield study and the decline in vaccinations that it has wrought has to some extent overshadowed the news of real research on autism spectrum disorder (ASD). Discovering the molecular basis of ASD remains an ongoing area of interest, with genetic and epigenetic factors implicated in addition to potential… Read article →


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Biological parameters involved in EEC tumor progression

Editor’s note: This is a repost of an original story by QIAGEN Bioinformatics. Visit their blog for the original post and more bioinformatics-related stories here!)  Role of microRNA-mRNA interactions in Endometrioid Endometrial Carcinoma, a Sample to Insight biological exploration Endometrial adenoarcinoma is a common cause of gynecological cancer death in Europe and North America. The… Read article →