Whole-genome sequencing as a tool in the diagnosis and characterization of norovirus

If you’ve never had norovirus, consider yourself one of the few and fortunate. Norovirus is the most common cause of acute gastroenteritis among adults and children in the United States with symptoms including fever, vomiting and diarrhea. It causes 19–21 million illnesses and contributes to 56,000–71,000 hospitalizations and 570–800 deaths yearly (1). The virus is… Read article →


Now trending: the use of liquid biopsy to monitor tumor dynamics

Trends on social media and internet search engines can be used as tools to provide up-to-the-minute public opinion on just about any topic, from movies to presidential candidates. Liquid biopsy may be able to provide the same type of real-time (although not instantaneous) information about therapeutic efficacy as well as emerging drug resistance. Solid tumor… Read article →


Biobanking: the impact of low-concentration storage on RNA integrity

Biobanks frequently freeze samples to store them for future research use, but maintaining quality of nucleic acids under frozen conditions can be tricky. Following specific quality practices can ensure the preservation of RNA, which is crucial for maintaining samples for clinical studies. Storage conditions, including the temperature and the length of time tissues and purified RNA stay… Read article →


Cryopreservation of human mesenchymal stem cells for clinical applications

Mesenchymal stem cells (MSCs) are anchorage-dependent, non-hematopoietic fibroblast-like stem cells with multi‑lineage potential. They can be induced to differentiate into many cell types, including osteoblasts, myoblasts, adipocytes and chondrocytes. Although they were originally detected in bone marrow, they have also been found in dental pulp, adipose tissue and amniotic fluid. More than 500 clinical trials… Read article →