next-generation sequencing

From sample to insight: NGS for liquid biopsy and beyond

The use of high-throughput next-generation sequencing (NGS) technologies continues to provide a wealth of sequence data, resulting in significant advances in a wide range of research areas and applications. Key among these is liquid biopsy – the ability to sequence nucleic acids found in circulation will enable scientists to identify key mutations and more specifically distinguish… Read article →



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Circulating Biomarkers World Congress 2015

In March, the second annual SELECTBIO Circulating Biomarkers World Congress 2015 brought together academic researchers and industry participants to present research, industry and commercial activities in the translation of circulating biomarkers. Speakers presented unpublished data on extracellular vesicles and extracellular nucleic acids as circulating biomarkers, fitting into three overarching themes: • Circulating DNA, RNA and… Read article →


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Meet the challenges of single cell analysis

Single cell analysis is crucial for studying cellular diversity and heterogeneity in a complex mixture of materials. Whether you’re studying single cell genomics, circulating tumor cells or the microbiome, analyzing single cells creates the potential for deep understanding of cell heterogeneity. But several challenges stand in the way of this goal, such as allelic drop-out,… Read article →


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Profiling microRNA from exosomes and blood

Exosomes are nano-sized vesicles, secreted by all types of cells and found abundantly in biofluids like blood, saliva and urine. These extracellular vesicles carry multiple functional passengers including DNA, miRNA, non-coding RNA and proteins, and function as intercellular communication vehicles by transporting molecules between specific cells. microRNAs are small non-coding RNAs that play an intricate… Read article →