Tumor-derived exosomes

Tumor cells utilize multiple signaling mechanisms to modify surrounding tissue and create a favorable environment for growth and metastasis. Direct cell–cell communication is mediated by gap junctions, which are specialized channels that allow the transfer of ions and small molecules between adjacent cells. Paracrine signaling molecules, such as TGF-beta and fibroblast growth factor, act over a… Read article →


Detection of chromosomal rearrangements

Recently in Nature, Cheng-Zhong Zhang and colleagues published a very interesting approach that provides the first direct experimental evidence for a mechanism leading to chromothripsis (1). What exactly is chromothripsis? Zhang’s publication piqued my interest to dig a bit deeper into this phenomenon. Chromothripsis is a kind of catastrophic mutational event that results in massive rearrangements… Read article →


New webinar shows synergy between two miRNA detection techniques

In our last post, we discussed the strengths and weaknesses of the three most popular techniques for miRNA detection, qPCR, miRNA-seq and microarray. We ultimately concluded that these miRNA detection technologies are appropriate for different experimental circumstances, and a lab’s decision about which to use should be driven by their research goals. Today, I’m excited to report on a presentation about… Read article →