Critical factors in the retrieval of usable analytes from FFPE samples

The process of retrieving analytes from formalin-fixed paraffin-embedded (FFPE) tissue samples is an incredibly complicated endeavor. There are several major challenges when purifying DNA, RNA and protein from FFPE samples. First, these biomolecules are crosslinked to each other. Second, nucleic acids are often fragmented depending how the FFPE samples are prepared, and third, there is… Read article →


Liquid biopsy: a necessity in the age of personalized medicine

The 2001 introduction of Imatinib (Gleevec) for the treatment of chronic myelogenous leukemia was a watershed moment in cancer therapeutics. In addition to treating a previously fatal leukemia, it opened the door for the further development of targeted therapeutics, molecules designed to specifically inhibit individual oncogenic proteins. The advent of targeted therapy also made the… Read article →


Top 5 considerations for preparing and archiving FFPE samples

The archives of formalin-fixed paraffin-embedded (FFPE) tissue sections stored around the world represent a valuable and extensive source of material for biomedical research. With more researchers turning towards molecular analysis of FFPE samples, it is becoming increasingly important to develop specific protocols that take into consideration the unique nature of these samples. The complete FFPE… Read article →