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Detection of chromosomal rearrangements

Recently in Nature, Cheng-Zhong Zhang and colleagues published a very interesting approach that provides the first direct experimental evidence for a mechanism leading to chromothripsis (1). What exactly is chromothripsis? Zhang’s publication piqued my interest to dig a bit deeper into this phenomenon. Chromothripsis is a kind of catastrophic mutational event that results in massive rearrangements… Read article →




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New webinar shows synergy between two miRNA detection techniques

In our last post, we discussed the strengths and weaknesses of the three most popular techniques for miRNA detection, qPCR, miRNA-seq and microarray. We ultimately concluded that these miRNA detection technologies are appropriate for different experimental circumstances, and a lab’s decision about which to use should be driven by their research goals. Today, I’m excited to report on a presentation about… Read article →


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Critical factors in the retrieval of usable analytes from FFPE samples

The process of retrieving analytes from formalin-fixed paraffin-embedded (FFPE) tissue samples is an incredibly complicated endeavor. There are several major challenges when purifying DNA, RNA and protein from FFPE samples. First, these biomolecules are crosslinked to each other. Second, nucleic acids are often fragmented depending how the FFPE samples are prepared, and third, there is… Read article →