Posts Tagged: blood

Exosomes

Is ultracentrifugation still the gold standard for exosome isolation?

There’s a new, proven method that may be knocking ultracentrifugation from its perch. Liquid biopsies and biomarker research depend on reliable access to exosomes and other extracellular vesicles (EVs), but standard ultracentrifugation-based protocols are laborious and don’t yield standardized results. Traditional ultracentrifugation-based protocols to isolate EVs are labor-intensive and subject to significant variability. Various attempts to… Read article →


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Could microRNAs be potential biomarkers for autism?

The attention in recent years surrounding the falsified Andrew Wakefield study and the decline in vaccinations that it has wrought has to some extent overshadowed the news of real research on autism spectrum disorder (ASD). Discovering the molecular basis of ASD remains an ongoing area of interest, with genetic and epigenetic factors implicated in addition to potential… Read article →



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Circulating tumor cell (CTC) biomarkers in liquid biopsy – not ready for prime time?

Currently, the only FDA-approved use of circulating tumor cells (CTCs) is identifying and counting CTCs in whole blood from patients with metastatic breast, colon or prostate cancer (1). Based upon recent developments, enumeration of CTCs is only the tip of the iceberg. Molecular characterization of CTCs would permit noninvasive genotyping in real time, potentially sampling… Read article →