Posts Tagged: blood

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Circulating tumor cell (CTC) biomarkers in liquid biopsy – not ready for prime time?

Currently, the only FDA-approved use of circulating tumor cells (CTCs) is identifying and counting CTCs in whole blood from patients with metastatic breast, colon or prostate cancer (1). Based upon recent developments, enumeration of CTCs is only the tip of the iceberg. Molecular characterization of CTCs would permit noninvasive genotyping in real time, potentially sampling… Read article →



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A webinar with Dr. Jo Vandesompele – Expanding the dynamic range of microRNA expression

In 2014, an ambitious microRNA technology study was published in Nature Methods. This study evaluated the existing microRNA platforms on the market for their technical performance. The authors, including first author Pieter Mestdagh and corresponding author Jo Vandesompele of Ghent University and Biogazelle, found small differences between the qPCR technologies, but concluded that from this purely technical perspective, there was no… Read article →


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Why preamplify in miRNA research? Download the white paper

It’s hard to overstate the importance of amplification technology in molecular biology. Reverse transcription-polymerase chain reaction (RT-PCR) amplifies sections of messenger RNA so they can be quantified – we’d have a much dimmer view of the transcriptome without it. Whole-genome amplification helps us analyze genes in single or limited cells, opening up a whole new… Read article →


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Webinar download: Automate and standardize processes for cell-free DNA in liquid biopsy

Circulating, cell-free DNA (cfDNA), which can originate from malignant tumors, the developing fetus or inflammatory tissues, is present among the cell-free nucleic acids in plasma, serum and other body fluids. Recently, cfDNA has become a powerful tool in non-invasive prenatal testing (NIPT), as well as in liquid biopsy for cancer. Analysis of cfDNA allows for… Read article →