Posts Tagged: cancer

ILLU_0890_SingleCell_HeterogeneityTumorPeople (1)

The details in the differences – painting a clearer picture of tumor heterogeneity

To say tumor biology is complex is an understatement. Not only can tumors vary genetically, phenotypically and metabolically, there are even differences in cells within a single tumor. Collectively, this is referred to as tumor heterogeneity, and is used as a basis for the classification of tumors into subtypes, predominantly based on cancer-specific genomic or… Read article →



BreastCancer_700x233

New webinar: HER2, CTCs and tumor stemness

About 20–30% of breast cancer tumors overexpress the oncogene human epidermal growth factor receptor 2 (HER2), which – if not treated with a targeted anti-HER2 regimen – leads to higher aggressiveness and mortality. Recently, a number of studies have shown that expression of HER2 in circulating tumor cells (CTCs) varies compared to expression in primary tumors…. Read article →


ILLU_0890_SingleCell_HeterogeneityTumorPeople (1)

Understanding tumor heterogeneity with gene expression analysis

Strategies to counter tumor heterogeneity are high on the wish list of oncologists and cancer researchers. Within a single tumor, cells can differ in size, proliferation rate and ability to metastasize. Most significantly for physicians and patients, they can also differ in their sensitivity to chemotherapy. How can we best understand and investigate this aspect… Read article →


Epigenetics

Epigenetics research and its significance in cancer

Introduction to epigenetics and techniques There has been a great interest in the study of epigenetic mechanisms and DNA methylation in many areas of research, including DNA repair, cell cycle control, developmental biology, cancer research, identification of biomarkers, predisposition factors and potential drug targets. Lately I’ve been immersed in this field via my close work… Read article →