Posts Tagged: cancer


Tumor-derived exosomes

Tumor cells utilize multiple signaling mechanisms to modify surrounding tissue and create a favorable environment for growth and metastasis. Direct cell–cell communication is mediated by gap junctions, which are specialized channels that allow the transfer of ions and small molecules between adjacent cells. Paracrine signaling molecules, such as TGF-beta and fibroblast growth factor, act over a… Read article →


Liquid biopsy: a necessity in the age of personalized medicine

The 2001 introduction of Imatinib (Gleevec) for the treatment of chronic myelogenous leukemia was a watershed moment in cancer therapeutics. In addition to treating a previously fatal leukemia, it opened the door for the further development of targeted therapeutics, molecules designed to specifically inhibit individual oncogenic proteins. The advent of targeted therapy also made the… Read article →