Posts Tagged: cancer

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Breaking the metastasis cycle: Is ROS-activated β-globin expression required for CTC survival?

Reactive oxygen species (ROS) are chemical molecules containing a highly reactive oxygen molecule. These molecules are formed as by-products of cellular metabolism, but also serve intracellularly as signaling molecules. ROS examples include peroxides, superoxide, hydroxyl radical and singlet oxygen. When present within cells in significant amounts, ROS can be indicators of oxidative cellular stress, and… Read article →


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A day in the life of a cancer researcher

The song “A day in the life” sung by The Beatles has always been one of my favorites and probably the reason why many people contemplate what they do in their daily lives. Although I moved from academia to industry several years ago, I still have good friends working as post-doctorates who are specifically involved… Read article →


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The details in the differences – painting a clearer picture of tumor heterogeneity

To say tumor biology is complex is an understatement. Not only can tumors vary genetically, phenotypically and metabolically, there are even differences in cells within a single tumor. Collectively, this is referred to as tumor heterogeneity, and is used as a basis for the classification of tumors into subtypes, predominantly based on cancer-specific genomic or… Read article →



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New webinar: HER2, CTCs and tumor stemness

About 20–30% of breast cancer tumors overexpress the oncogene human epidermal growth factor receptor 2 (HER2), which – if not treated with a targeted anti-HER2 regimen – leads to higher aggressiveness and mortality. Recently, a number of studies have shown that expression of HER2 in circulating tumor cells (CTCs) varies compared to expression in primary tumors…. Read article →