Posts Tagged: cancer


The key to a deeper understanding of cancer – single cell genomics

Three hundred years ago, the father of microbiology, Anton van Leeuwenhoek, observed single-celled organisms for the first time. Three hundred years later, advances in next-generation sequencing (NGS) and whole genome amplification (WGA) technologies now enable us to decode the genetic differences between single cells. This ability has tremendous implications for the field of cancer research. Nowadays we… Read article →


CTCs as prognostic markers for metastatic breast cancer

Circulating tumor cells (CTCs) are tumor cells circulating freely in the peripheral blood of patients. The characterization of CTCs is considered as a real-time “liquid biopsy” that provides an ongoing picture of a patient’s cancer status, offering valuable insight into personalized anticancer therapy. CTCs are very rare and highly heterogeneous, possessing tumor-specific antigenic and genetic characteristics. One… Read article →


What enables drug resistance in ER+ breast cancer cells?

Chemoresistance is the bane of cancer therapy. Living things react and adapt to their environments; it would be convenient if cancer cells were the exception, but there are countless examples of a previously effective chemotherapy rendered impotent by a cancer’s adaptation. One of the major challenges in cancer research, then, is to decipher these adaptations… Read article →