Posts Tagged: cancer

Epigenetics

Epigenetics research and its significance in cancer

Introduction to epigenetics and techniques There has been a great interest in the study of epigenetic mechanisms and DNA methylation in many areas of research, including DNA repair, cell cycle control, developmental biology, cancer research, identification of biomarkers, predisposition factors and potential drug targets. Lately I’ve been immersed in this field via my close work… Read article →


QIAseq_ProductFamily_700x233

Novel digital sequencing technology promises to advance oncology research

As research uncovers the underlying mutations and mechanisms that drive oncogenesis and cancer progression, it’s becoming clearer that cures are likely to come not from a single silver bullet, but from identifying each individual’s personal cancer drivers. Next-generation sequencing (NGS) is the leading strategy for finding sequence variants and fusion genes responsible for cancer, and targeted… Read article →


Tcell_WBC_SingleCell_BLUE_BG_580x200

The PD1 race picks up pace

If you’ve been following developments in cancer immunotherapy closely, you’ve probably heard of programmed death 1 (PD1/PDCD1, also known as CD279) and PDL1 (CD274). Their interaction is at the center of new immune checkpoint-targeting therapies coming out of the pharmaceutical industry, such as Bristol-Myers Squibb’s nivolumab and Merck’s pembrolizumab (1, 5). What are PD1 and PDL1, and… Read article →



Biogenesis

Back to the beginning: microRNA biogenesis

Introduction Since the discovery of microRNA (miRNA) in the early 1990s, much effort has been devoted to understanding how miRNAs are produced in the cell and how genes are controlled by these tiny RNAs. In today’s blog, we look back to the very beginning of miRNA discovery, and discuss miRNA biogenesis and its influence in cancer… Read article →