Posts Tagged: cancer

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Novel digital sequencing technology promises to advance oncology research

As research uncovers the underlying mutations and mechanisms that drive oncogenesis and cancer progression, it’s becoming clearer that cures are likely to come not from a single silver bullet, but from identifying each individual’s personal cancer drivers. Next-generation sequencing (NGS) is the leading strategy for finding sequence variants and fusion genes responsible for cancer, and targeted… Read article →


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The PD1 race picks up pace

If you’ve been following developments in cancer immunotherapy closely, you’ve probably heard of programmed death 1 (PD1/PDCD1, also known as CD279) and PDL1 (CD274). Their interaction is at the center of new immune checkpoint-targeting therapies coming out of the pharmaceutical industry, such as Bristol-Myers Squibb’s nivolumab and Merck’s pembrolizumab (1, 5). What are PD1 and PDL1, and… Read article →



Biogenesis

Back to the beginning: microRNA biogenesis

Introduction Since the discovery of microRNA (miRNA) in the early 1990s, much effort has been devoted to understanding how miRNAs are produced in the cell and how genes are controlled by these tiny RNAs. In today’s blog, we look back to the very beginning of miRNA discovery, and discuss miRNA biogenesis and its influence in cancer… Read article →


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Emerging roles of competing endogenous RNA (ceRNA)

If you have been following our blog posts about microRNA (miRNA) – or if you have been studying the microRNA world – you are likely familiar with the small 22-nucleotide RNAs that target messenger RNAs (mRNAs) to repress their translation into protein. The ceRNA hypothesis In 2011, Pier Paolo Pandolfi research lab proposed the hypothesis… Read article →