Posts Tagged: CTC

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The power of immunomagnetic CTC detection – Meet the AdnaTest family

The importance of circulating tumor cells (CTCs) in cancer research is broadly accepted in the scientific community today. Since CTCs undergo phenotypic changes known as the epithelial-to-mesenchymal transition (EMT), they are a valuable indicator for disease progression and therapy resistance. To learn from CTCs, we must be able to effectively detect and characterize them. There… Read article →


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New ideas abound at ACTC 2017: Mitochondria and metastasis, new prostate cancer CTC tools and more!

The 3rd ACTC Advances in Circulating Tumor Cells Conference was held in Rhodes, Greece October 4-7, 2017. This idyllic island setting off the coast of Turkey provided a relaxed and welcoming atmosphere for discussing the latest advances in cancer and circulating tumor cell research. Talks were divided into 6 plenary lecture sessions consisting of: (1)… Read article →


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Getting Multiplex PCR gene expression profiling working for you

Multiplex PCR is an extremely enabling molecular biology technique, allowing the amplification of multiple targets in a single PCR experiment. There are a broad range of research applications for multiplex PCR, including pathogen identification, high-throughput SNP genotyping, gene expression profiling, template quantitation, RNA detection and even forensic studies. Gene expression profiling of CTCs  The presence… Read article →



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Breaking the metastasis cycle: Is ROS-activated β-globin expression required for CTC survival?

Reactive oxygen species (ROS) are chemical molecules containing a highly reactive oxygen molecule. These molecules are formed as by-products of cellular metabolism, but also serve intracellularly as signaling molecules. ROS examples include peroxides, superoxide, hydroxyl radical and singlet oxygen. When present within cells in significant amounts, ROS can be indicators of oxidative cellular stress, and… Read article →