Posts Tagged: CTC

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The Future’s So Bright: Liquid Biopsy in 2016

Basic scientists, clinicians and market analysts are all optimistic about the prospects for liquid biopsy in 2016. Several reports have determined that liquid biopsy is a growing market segment for cancer diagnosis and management (1–2), expected to reach $20 billion in the next five years (1). Biotech startups and major companies alike have jumped in… Read article →


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How might regulatory RNAs impact CTC analysis?

Liquid biopsy, the concept of discovering or monitoring disease by a simple blood test or other biofluid, overcomes many of the challenges of a traditional tissue biopsy. It’s less invasive, and simplifies collection of multiple samples over the course of disease progression and treatment. It’s not an overstatement to say that liquid biopsy is revolutionizing… Read article →


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Small RNAs in small samples – what’s the value in single-cell microRNA analysis?

microRNA profiling has revolutionized our understanding of gene regulation. Technological advances are now enabling us to drill down further to the fine details – small RNA sequencing to identify undiscovered microRNAs, for example, preamplification to improve qPCR results from small samples and kits to reveal the small RNA contents of exosomes. Single-cell analysis is an… Read article →


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CTCs and their central role in metastatic cascade, tumor dissemination and progression

Circulating tumor cells (CTCs) can be detected from the peripheral blood of cancer patients, and are viewed as a unique “liquid biopsy” for cancer prognosis and diagnosis (1). Unlike other cancer biomarkers, CTCs represent a sampling of the patient’s primary tumor. Furthermore, CTCs play a crucial role in tumor dissemination and progression, and are widely… Read article →


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Sampling of CTCs reveals drug-resistance mechanisms in prostate cancer

CTC clusters: biological significance and label-independent isolation using microchip technology Clusters of CTCs, consisting of two or more cells, have been observed for decades. Their significance is unknown, but a recent study suggests that a cluster is approximately 50 times more likely to result in a metastatic event compared to a single CTC (1). In… Read article →