Posts Tagged: DNA


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Impact of storage buffer and temperature of stored DNA on PCR amplification products

In today’s clinical and translational research, blood is one of most common biospecimens being used. Although the highest DNA yield and quality is achieved by purifying genomic DNA from freshly harvested material, regretfully most of our precious samples cannot be processed straight away. That´s why sample management is so crucial right from the very start…. Read article →


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Barcodes in NGS: sample vs molecular

NGS data can be extremely complex, and technology that helps improve the accuracy of data analysis can make the difference between drawing the right conclusions or the wrong ones. Sample and molecular barcodes serve roughly the same purpose as barcodes in any other context – they’re unique identifiers that distinguish and group like items together. But unless you’ve… Read article →


Epigenetics

Epigenetics research and its significance in cancer

Introduction to epigenetics and techniques There has been a great interest in the study of epigenetic mechanisms and DNA methylation in many areas of research, including DNA repair, cell cycle control, developmental biology, cancer research, identification of biomarkers, predisposition factors and potential drug targets. Lately I’ve been immersed in this field via my close work… Read article →


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Novel digital sequencing technology promises to advance oncology research

As research uncovers the underlying mutations and mechanisms that drive oncogenesis and cancer progression, it’s becoming clearer that cures are likely to come not from a single silver bullet, but from identifying each individual’s personal cancer drivers. Next-generation sequencing (NGS) is the leading strategy for finding sequence variants and fusion genes responsible for cancer, and targeted… Read article →