Posts Tagged: drug

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The PD1 race picks up pace

If you’ve been following developments in cancer immunotherapy closely, you’ve probably heard of programmed death 1 (PD1/PDCD1, also known as CD279) and PDL1 (CD274). Their interaction is at the center of new immune checkpoint-targeting therapies coming out of the pharmaceutical industry, such as Bristol-Myers Squibb’s nivolumab and Merck’s pembrolizumab (1, 5). What are PD1 and PDL1, and… Read article →


Antibiotic resistance

Combating drug-resistant superbugs

Antibiotics have been used for the last 80 years to treat patients with bacterial infections. While antibiotics have greatly reduced illness and death resulting from these infections, their use has been so prevalent that microbes have adapted to them, eliminating their effectiveness. These microbes are named antibiotic-resistant superbugs. Superbugs can acquire resistance genes either by… Read article →



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Signs of an overdose – microRNAs identify drug toxicity

When we think of drug overdoses, we typically think of controlled substances – e.g., illegal drugs or prescription drug abuse. It might come as a surprise, then, to hear that overdose of acetaminophen (APAP), the common over-the-counter analgesic used for headaches, fevers, and other minor ailments, is also a serious public health concern. Data from… Read article →