Posts Tagged: epigenetics

Epigenetics

Epigenetics research and its significance in cancer

Introduction to epigenetics and techniques There has been a great interest in the study of epigenetic mechanisms and DNA methylation in many areas of research, including DNA repair, cell cycle control, developmental biology, cancer research, identification of biomarkers, predisposition factors and potential drug targets. Lately I’ve been immersed in this field via my close work… Read article →


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Webinar takeaways – “Accurate DNA Methylation Analysis by Successful Bisulfite Conversion”

DNA methylation is widely recognized as a major player regulating normal gene expression and facilitating chromatin organization within cells. Research into abnormal DNA methylation that leads to human diseases like cancer could therefore provide valuable insights for disease development diagnosis and potential therapies. DNA is made up of 4 nucleotides – cytosine, guanine, thymine and… Read article →


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What are the keys to successful bisulfite conversion?

Bisulfite conversion is the most popular method for DNA methylation analysis and the most convenient and effective way to map DNA methylation to individual bases. Yet there are many things to consider in order for you to get reliable results. In particular, the bisulfite treatment of DNA and the resulting conversion of unmethylated cytosines to… Read article →


Epigenetics

Location, location, location: methylation analysis for epigenetic research

No, we’re not talking about real estate! In research, location is key to how DNA methylation works. Epigenetics, the study of chromatin-modifying marks that do not alter DNA sequences, has recently undergone a paradigm shift regarding the effect of DNA methylation on gene transcription. In the human genome, the most commonly studied epigenetic mark is 5-methylcytosine, often… Read article →