Posts Tagged: lncRNA


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Emerging roles of competing endogenous RNA (ceRNA)

If you have been following our blog posts about microRNA (miRNA) – or if you have been studying the microRNA world – you are likely familiar with the small 22-nucleotide RNAs that target messenger RNAs (mRNAs) to repress their translation into protein. The ceRNA hypothesis In 2011, Pier Paolo Pandolfi research lab proposed the hypothesis… Read article →


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Multiple sclerosis: hunting for new RNA markers in blood

Multiple sclerosis (MS), a rare and chronic central nervous system disorder resulting from autoimmunity, occasionally steps into the public eye when it strikes a well-known person (such as in 1999, when talk show host Montel Williams revealed his diagnosis). In neuroscience and immunology laboratories, however, the disease is always a major topic of investigation. Researchers… Read article →


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Neurodegeneration: role of noncoding RNA in molecular mechanisms

Neurodegeneration is characterized by cumulative dysfunction and death of cells in selected areas of the nervous system. Neurodegenerative disorders typically present in old age with symptoms related to movement and cognition. The greatest burden of disease in the US, by number of individuals affected, is caused by Alzheimer’s disease (AD) (1). Characteristics of AD include… Read article →


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Join us to learn how lncRNA impacts cancer and microRNA regulation!

Long noncoding RNA are a non-protein-coding RNA species >200 nt in length that have been the subject of intense scrutiny recently. Research in the last several years has revealed roles for lncRNA in gene regulation at many levels – transcription, post-transcription, and in epigenetic modification. Many lncRNAs are dysregulated in various cancer types and are… Read article →