Posts Tagged: microRNA

miRNA_GameBoard_700x233

Where to tread carefully – how to ensure reliability in microRNA biomarker studies

Accuracy, reliable controls and reproducibility. These are the foundations on which a healthy scientific literature is based. When we read papers, we check the methods section to see how the authors controlled for certain variables, whether the technologies used were appropriate for the question, and how many times the experiments were replicated. Everyone wants to find the… Read article →



Detached_Retina_700x233

Keeping an eye on microRNA in retinal degeneration

The field of microRNA research is in a period of inflection. While RNAi and microRNA have been growing in prominence since discoveries by Dr. Craig Melo and Dr. Andy Fire looking at the relationship of small, non-coding RNA with gene expression, there has been a growing sense of the importance of detecting and correlating microRNA… Read article →


serum+plasma_miRNA_700x233

microRNAs in cancer metastasis: potential for therapy and liquid biopsy

For patients with solid tumors, metastatic disease often represents a turning point in their journey. It remains the most significant hurdle in cancer treatment, accounting for 90% of all deaths resulting from solid tumors (1). Research during the past 20 years has begun to elucidate multiple events that take place during metastatic progression. In the… Read article →


LungCancer+miRNA_700x233

Cancer in the lungs? The blood will tell – miRNA in non-small cell lung cancer

In a previous post, we discussed how small non-coding RNAs could be identified to serve as circulating biomarkers in lung cancer. Now, a new study from Ma et al. defines a promising microRNA signature in peripheral blood mononuclear cells. The signature can distinguish non-small cell lung carcinoma (NSCLC) with 72.62% sensitivity and 82.61% specificity, and squamous… Read article →