Posts Tagged: WGA


Application of single cell technology in genome editing

The development and widespread adoption of new genome editing techniques in basic and clinical research have yielded an impressive number of success stories and hold great promise for the treatment of diseases with a genetic component, gene therapy and synthetic biology. In particular, the recent explosion in genome editing due to CRISPR-Cas and similar systems… Read article →


The key to a deeper understanding of cancer – single cell genomics

Three hundred years ago, the father of microbiology, Anton van Leeuwenhoek, observed single-celled organisms for the first time. Three hundred years later, advances in next-generation sequencing (NGS) and whole genome amplification (WGA) technologies now enable us to decode the genetic differences between single cells. This ability has tremendous implications for the field of cancer research. Nowadays we… Read article →


Metagenomics and microbial single cell genomics – a winning team

Deciphering the world around us – the “microbial dark matter” (1) – is a remaining challenge in environmental microbiology. Even after decades of 16S rRNA gene-based surveys, there are strong indications that the diversity of bacteria is still not exhaustively described even on high taxonomic (phylum) levels and that 16S rRNA sequences, representing novel bacterial… Read article →


Whole-genome sequencing as a tool in the diagnosis and characterization of norovirus

If you’ve never had norovirus, consider yourself one of the few and fortunate. Norovirus is the most common cause of acute gastroenteritis among adults and children in the United States with symptoms including fever, vomiting and diarrhea. It causes 19–21 million illnesses and contributes to 56,000–71,000 hospitalizations and 570–800 deaths yearly (1). The virus is… Read article →