Any genetic variance analysis requires at least 1 ng of input DNA. However, a single bacterial or human cell contains only 1 fg or 1 pg genomic DNA, so whole genome amplification is a must. This raises a key question: what’s the best way to amplify the entire genome? Whole genome amplification can be classified into two… Read article →
Single cell analysis is crucial for studying cellular diversity and heterogeneity in a complex mixture of materials. Whether you’re studying single cell genomics, circulating tumor cells or the microbiome, analyzing single cells creates the potential for deep understanding of cell heterogeneity. But several challenges stand in the way of this goal, such as allelic drop-out,… Read article →
Cell types share many traits, like specific markers on their surface, or the ability to make a particular molecule. But does that mean every cell of a certain type behaves the same way? Not necessarily. Many experiments are done on large groups of cells – tens or hundreds of thousands of a single type, cultured… Read article →
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